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The modern-day provisions of the law applied to inventions are laid out in Title 35 of the United States Code (Ch. In 1873, Levi Strauss and Jacob Davis co-invented and co-patented the idea of using copper rivets at the stress points of sturdy work pants.

After one of Davis' customers kept purchasing cloth to reinforce torn pants, he had an idea to use copper rivets to reinforce the points of strain, such as on the pocket corners and at the top of the button fly.

This nanoparticle formulation provides new and promising properties, including overcoming the mechanisms of chemoresistance developed by tumor cells that affect the efficacy of chemotherapy agents. The new patent provides protection of the associated claims in the U. until 2032, and is in addition to the previously issued patents for the same patent family in other major territories, such as Europe and Japan.

(Euronext Paris: ONXEO) (NASDAQ Copenhagen: ONXEO), a clinical-stage biotechnology company specializing in the development of innovative drugs for the treatment of orphan diseases, in particular in oncology, today announced that it has received a Notice of Allowance from the U. Patent and Trademark Office for a patent application covering the specific route of administration for Livatag (doxorubicin Transdrug™) is based on an innovative technology allowing the formulation of doxorubicin (a chemotherapeutic agent) within nanoparticles composed of polyalkylcyanoacrylate, cyclodextrin, and poloxamer.

Such statements involve certain known and unknown risks, uncertainties and other factors, which could cause the actual results, financial condition, performance or achievements of Onxeo to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements.

Onxeo is providing this communication as of this date and does not undertake to update any forward-looking statements contained herein as a result of new information, future events or otherwise.

The knuckle coupler have a bifurcated drawhead and a revolving hook, which, when brought in contact with another coupler, automatically interlocks with its mate.

Knuckle couplers replaced the much more dangerous link-and-pin couplers and became the basis for standard coupler design for the rest of the 19th century. patent #147,119 was filed on January 22, 1874, and issued to Francis on February 3, 1874.

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inventions from other historical time periods, please see Timeline of United States inventions (1890–1945), Timeline of United States inventions (1946–1991), and Timeline of United States inventions (after 1991).

Onxeo’s comprehensive portfolio features a broad orphan oncology pipeline, with 3 major products in several on-going preclinical and clinical programs, alone or in combination for various cancer indications.

The Company is headquartered in Paris, France with offices in Copenhagen and in New York, and has approximately 60 employees.

For a discussion of risks and uncertainties which could cause actual results, financial condition, performance or achievements of Onxeo to differ from those contained in the forward-looking statements, please refer to the Risk Factors ("Facteurs de Risque") section of the 2016 Reference Document filed with the AMF on April 24, 2017, which is available on the AMF website ( or on the company’s website (

Blaisdell's world-famous guarantee that "It works or we fix it free™" still covers every Zippo windproof pocket lighter today.