They won't damage your kidneys, liver, heart, or nervous system. A few patients stop taking tricyclic antidepressants because the side effects are too annoying: dry mouth, constipation, sweating, or grogginess.Usually you can get through the start-up period when these symptoms are the worst by starting at a low dose, waiting until side effects go away, and then gradually increasing the dose step by step.Subclasses include: the tricyclic antidepressants (e.g., amitriptyline and doxepin); the serotonin-specific reuptake inhibitors (SSRI) including fluoxetine (Prozac); monoamine oxidase inhibitors (MAOIs), including phenelzine (Nardil); and several new drugs such as venlafaxine (Effexor) and nefazodone (Serzone). (2004) cites EMCDDA (1999) who reviewed controlled experimental studies and concluded that impaired performance is associated with the use of most sedative tricyclic antidepressants.New-generation antidepressants do not seem to interfere with performance, except when used at higher doses.Antidepressants are prescribed most often for clinical depression and severe cases of depression.Jones, Shinar, and Walsh (2003) provide a breakdown of the subclasses of antidepressants with examples.
The tricyclic antidepressants had little effect on the SDLP after one week of treatment, but the effect of mianserin persisted throughout the treatment period.
Occasionally a side effect limits your ability to take this medication at all.
The most common problem is developing "the munchies": a craving to eat sweets that can lead to gaining weight.
Examples of nonsedating antidepressants include the monoamine oxidase inhibitor moclobemide, the selective serotonin reuptake inhibitors fluoxetine, paroxetine, and nefazodone, and the serotonin and norepinephrine uptake inhibitor (SNRI) venlafaxine.
The effect of antidepressants on driving behavior was assessed with the standard deviation of lateral position (SDLP) test.